Hmm, so after keeping CDP-S100 unplugged for an extended amount of time [a number of times I did this] as this is the only thing I could think of to maybe 'discharge the static electricity from the board' all the keys are working now! Not sure if this is what fixed it but its magically working again this morning!
Of note, I do recall a really big thunder storm when this problem occurred. Investing in a 'power surge protector'!
Thanks for you help Mike.